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The ketolide antibiotic ABT-773 is a specific inhibitor of translation and 50s ribosomal subunit formation in Streptococcus pneumoniae cells

ABT-773 is a new 3-keto macrolide antibiotic that has been shown to be very effective against infections by Gram-positive microorganisms. This work examines its inhibitory effects in cells of Streptococcus pneumoniae. ABT-773 caused a proportional decline in cell growth rates and viability with an IC50 of 5 ng/ml. Protein synthesis in these cells was reduced by 50% at an antibiotic concentration of 2.5 ng/ml. This compound was also found to be a very effective online pharmacy viagra of the formation of the 50S ribosomal subunit in growing cells. Pulse and chase labeling assays revealed a reduced rate of 50S synthesis in antibiotic-treated cells. At 2 ng/ml, the rate was reduced to 33% of the control synthesis rate. An IC50 of 5 ng/ml was found for the effect on this process, indicating an equal effect of the drug on translation and assembly. Synthesis of the 30S ribosomal subunit was unaffected by this antibiotic. The effects of ABT-773 in S. pneumoniae are compared with those of the related ketolide antibiotic telithromycin in S. pneumoniae and in Staphylococcus aureus.

Midweek Ramblings- Viagra Cocktail, Chorizo de abulón, Fruit Salad and more

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I have been shooting food pics with point-and-shoot cameras for years now and decided to take my hobby to the next level with a Digital SLR. Yes I took the plunge and bought myself a Nikon D40.



I'm experiencing a learning curve but I hope to improve the quality of the images on my blog. One thing I'm adjusting to is the size difference. Trust me its not easy breaking out a D40 at a taco stand in Tijuana and clicking away.

I will still be using some archived images from my old camera, but you should gradually see a difference in picture quality. I have been using the camera for a few days now and here are some of the highlights.

"Viagra Cocktail" taken at a local San Diego taco truck.


Sope de Chorizo de abulón - La Querencia Tijuana


Fruit Salad - Frutilandia San Diego


Speaking of San Diego......
Lately I have tossed the idea around on including San Diegos Mex food scene on this site. I'm leaning towards including San Diego, I just don't know when and how. What are my issues on the decision? I have been active on San Diego food based Message Boards and Review Sites for a few years now, and I just don't feel comfortable using a copy and paste method of my past contributions. I would like to highlight the places I frequented in the past and also bring in a fresh new perspective.

In Ensenada news this week....

Degustation, food and wine tasting Spring Festival at Restaurante Del Parque and adjoining wine shop La Contra. Saturday March 21 2009 - 5:00pm - 8:30pm. See the banner below for more info.
Reservations: vinoslacontra@gmail.com
Tel. (646)178.8213 / (646)156.5260

Medical Research Fraud? - Autism and Vaccines

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Medical Research Fraud? - Autism and Vaccines

Released yesterday by the British Medical Journal: Secrets of the MMR scare: How the case against the MMR vaccine was fixed.  In this article Brian Deer details how the "facts" in the seminal paper linking Autism to MMR vaccinations do not match up with reality. Mr. Deer discovered that all 11 cases presented in the paper were altered from the available evidence.  The evidence was largely the medical records of the 11 children of the study, but also included interviews with the parents of the these children.  The article seems to point to deliberate fraud on the part of Andrew Wakefield (first author of the original study).



It is all about money.



Are we really surprised? The article points out Wakefield was on the payroll of some lawyers in the US who were putting together a case against the MMR vaccine manufacturer.  He was on the payroll before he started the study. 



Greed. 



In this day and age of medical research funded by drug companies (don't even get me started) and research fraud in all branches of science it is scary.  Fraud not withstanding, how does a medical order cialis discern the validity of these studies?  Most medical doctors are not researchers.  How do they evaluate the validity of a study? I suppose most doctors simply follow the official medical guidelines. But what about drugs?  They have to trust the journal and trust the FDA to catch things before they get to the population.  But how does the FDA regulate things like the GlaxoSmithKline debacle where drugs were being mixed together?



It sure is scary out there.  I don't worry about me so much, but my kids... they are small and little problems in a drug can have big effects on their little, developing bodies.